Prognostic utility of intact immunoglobulin Ig′κ/Ig′λ ratios in multiple myeloma patients
نویسندگان
چکیده
منابع مشابه
Prognostic Factors in Patients with Multiple Myeloma
That is why the morphology of myeloma cells is one of the most important prognostic factors of the disease [4]. There are also other prognostic factors associated with both malignant cell characteristics and the status of the host's immunocompetent system [7]. Taking into account the data on the decrease in colony-forming units granulocyte/macrophage (CFU-OM) in MM [2, 11], an~ the antitumor ef...
متن کاملImmunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients.
BACKGROUND To analyze the clinical features, outcomes including efficacy of treatment, and prognostic factors of patients with immunoglobulin D multiple myeloma (IgD MM). DESIGN AND METHODS Seventy-five patients diagnosed with IgD MM were selected from the Korean Myeloma Registry database (www.myeloma.or.kr). RESULTS Median age was 57 years and the main presenting features were bone pain (7...
متن کاملImmunoglobulin heavy and light chain isotypes in multiple myeloma patients.
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were o...
متن کاملA Tentative Staging of Multiple Myeloma by Utilizing Respective Coefficients of Prognostic Factors
Introduction: Multiple myeloma is a heterogeneous disease with different survival times among patients. Accurate prediction of prognosis in multiple myeloma is essential, as patients with a shorter survival time may require early bone marrow transplantation (BMT) and more advanced chemotherapy as a part of their first-line treatment. In the present study, a parameter, depicted by ga...
متن کاملPrognostic factors in multiple myeloma.
All patients with multiple myeloma seen over a 9-year period at Tygerberg Hospital were studied retrospectively. Presentation data of 144 patients, as well as individual laboratory results were included in the survival analysis. Cox's proportional hazard model (a non-parametric multivariate regression method) was used to predict survival and divide patients into prognostic groups. The relations...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2012
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2012.159